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Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading
المؤلفون المشاركون
Verde, Alessandro
Cozzi, Lorena
Barsanti, Cristina
D’Aurizio, Romina
El Baroudi, Mariama
Baumgart, Mario
Groth, Marco
Botta, Luca
Trivella, M. G.
Pitto, L.
Caruso, Raffaele
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Mechanical unloading by left ventricular assist devices (LVADs) in advanced heart failure (HF), in addition to improving symptoms and end-organ perfusion, is supposed to stimulate cellular and molecular responses which can reverse maladaptive cardiac remodeling.
As microRNAs (miRNAs) are key regulators in remodeling processes, a comparative miRNA profiling in transplanted hearts of HF patients with/without LVAD assistance could aid to comprehend underlying molecular mechanisms.
Next generation sequencing (NGS) was used to analyze miRNA differential expression in left ventricles of HF patients who underwent heart transplantation directly ( n = 9 ) or following a period of LVAD support ( n = 8 ).
After data validation by quantitative real-time PCR, association with functional clinical parameters was investigated.
Bioinformatics’ tools were then used for prediction of putative targets of modulated miRNAs and relative pathway enrichment.
The analysis revealed 13 upregulated and 10 downregulated miRNAs in failing hearts subjected to LVAD assistance.
In particular, the expression level of some of them (miR-338-3p, miR-142-5p and -3p, miR-216a-5p, miR-223-3p, miR-27a-5p, and miR-378g) showed correlation with off-pump cardiac index values.
Predicted targets of these miRNAs were involved in focal adhesion/integrin pathway and in actin cytoskeleton regulation.
The identified miRNAs might contribute to molecular regulation of reverse remodeling and heart recovery mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barsanti, Cristina& Trivella, M. G.& D’Aurizio, Romina& El Baroudi, Mariama& Baumgart, Mario& Groth, Marco…[et al.]. 2015. Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barsanti, Cristina…[et al.]. Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barsanti, Cristina& Trivella, M. G.& D’Aurizio, Romina& El Baroudi, Mariama& Baumgart, Mario& Groth, Marco…[et al.]. Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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