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Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes
المؤلفون المشاركون
Li, Qiuxia
Wei, Qiujing
Liao, Zetao
Lin, Zhiming
Zhang, Pingping
Mou, Yikun
Gu, Jieruo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Ankylosing spondylitis (AS) is a common rheumatic disease and is characterized by inflammation of the axial skeleton.
HLA-B27 is strongly associated with AS.
Juvenile-onset AS (JAS) with disease onset before 16 years of age differs from adult-onset AS (AAS) in many respects.
Objective.
To compare the clinical features in JAS with different B27 subtypes and analyze the differences between JAS and AAS.
Methods.
145 JAS and 360 AAS patients were included.
The demographic data, clinical manifestations, laboratory markers, Bath AS indices, and B27 subtypes were recorded.
Results.
Peripheral arthritis, enthesitis, BASDAI, ESR, and CRP were significantly higher in JAS patients with HLA- B * 2704 than those with B27-negative.
Enthesitis and ESR were significantly higher in patients with HLA- B * 2705 than those with B27-negative.
The onset age of HLA- B * 2715 group was much earlier than the other groups.
The peripheral arthritis, enthesitis, and hip joint involvement in JAS with HLA- B * 2704 were significantly higher than those in AAS with HLA- B * 2704.
Conclusion.
JAS with different B27 subtypes had similar features in most of manifestations; JAS and AAS patients with the same subtype could have distinctive courses.
Early diagnosis, hip detection, and control of systemic active inflammation in JAS patients will be helpful for improving the prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mou, Yikun& Zhang, Pingping& Li, Qiuxia& Lin, Zhiming& Liao, Zetao& Wei, Qiujing…[et al.]. 2015. Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mou, Yikun…[et al.]. Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mou, Yikun& Zhang, Pingping& Li, Qiuxia& Lin, Zhiming& Liao, Zetao& Wei, Qiujing…[et al.]. Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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