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The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes Taenia crassiceps Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection
المؤلفون المشاركون
Ledesma-Soto, Yadira
Terrazas, César A.
Montero-Barrera, Daniel
Valderrama-Carvajal, Héctor
Rojas-Hernández, Saúl
Vera-Arias, Laura
Carrasco-Yépez, Maricela
Gómez-García, Lorena
Martínez-Saucedo, Diana
Becerra-Díaz, Mireya
Terrazas, Luis I.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-15
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
C-type lectins are multifunctional sugar-binding molecules expressed on dendritic cells (DCs) and macrophages that internalize antigens for processing and presentation.
Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selectively expressed on immature DCs and macrophages.
Helminth parasites contain large amounts of glycosylated components, which play a role in the immune regulation induced by such infections.
Macrophages from MGL1−/− mice showed less binding ability toward parasite antigens than their wild-type (WT) counterparts.
Exposure of WT macrophages to T.
crassiceps antigens triggered tyrosine phosphorylation signaling activity, which was diminished in MGL1−/− macrophages.
Following T.
crassiceps infection, MGL1−/− mice failed to produce significant levels of inflammatory cytokines early in the infection compared to WT mice.
In contrast, MGL1−/− mice developed a Th2-dominant immune response that was associated with significantly higher parasite loads, whereas WT mice were resistant.
Flow cytometry and RT-PCR analyses showed overexpression of the mannose receptors, IL-4Rα, PDL2, arginase-1, Ym1, and RELM-α on MGL1−/− macrophages.
These studies indicate that MGL1 is involved in T.
crassiceps recognition and subsequent innate immune activation and resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montero-Barrera, Daniel& Valderrama-Carvajal, Héctor& Terrazas, César A.& Rojas-Hernández, Saúl& Ledesma-Soto, Yadira& Vera-Arias, Laura…[et al.]. 2015. The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes Taenia crassiceps Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montero-Barrera, Daniel…[et al.]. The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes Taenia crassiceps Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1056136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montero-Barrera, Daniel& Valderrama-Carvajal, Héctor& Terrazas, César A.& Rojas-Hernández, Saúl& Ledesma-Soto, Yadira& Vera-Arias, Laura…[et al.]. The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes Taenia crassiceps Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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