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Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway
المؤلفون المشاركون
Wu, Xinyu
Chen, Zhida
Zeng, Wengrong
Zhong, Yuanfu
Liu, Qingjun
Wu, Jin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
So far, the role of Ether à go-go 1 (Eag1) potassium channels in migration and invasion progression of cancers remains elusive.
In the present study, the effects of Eag1 knockdown on osteosarcoma cell proliferation, growth, and apoptosis were examined.
Then, we evaluated the effects of Eag1 silencing on osteosarcoma cell migration and invasion.
In addition, we detected the expression of vascular endothelial growth factor (VEGF) and signal transducer and activator of transcription 3 (STAT3) in osteosarcoma cell treated with Eag1 small interfering RNAs (siRNAs).
Finally, STAT3 siRNA was employed to determine the influence of downregulation of STAT3 on cell proliferation and migration.
The results showed that knockdown of Eag1 significantly suppressed osteosarcoma cell proliferation and osteosarcoma xenografts growth.
However, Eag1 silencing had little effect on cell apoptosis.
Additionally, osteosarcoma cell adhesion, migration, and invasion were also potently attenuated.
Notably, the expression levels of VEGF decreased evidently upon Eag1 siRNAs treatment, paralleled with reductions in the expression levels of STAT3.
Moreover, a similar pattern was observed in osteosarcoma cell proliferation and migration suppression between STAT3 siRNA and Eag1 siRNAs groups.
Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xinyu& Chen, Zhida& Zeng, Wengrong& Zhong, Yuanfu& Liu, Qingjun& Wu, Jin. 2015. Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xinyu…[et al.]. Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xinyu& Chen, Zhida& Zeng, Wengrong& Zhong, Yuanfu& Liu, Qingjun& Wu, Jin. Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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