Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

المؤلفون المشاركون

Zhang, Yu-Hang
Wan, Sibao
Wang, ShaoPeng
Yuan, Fei
Kong, Xiangyin

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-11-03

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Pancreatic cancer (PC) is a highly malignant tumor derived from pancreas tissue and is one of the leading causes of death from cancer.

Its molecular mechanism has been partially revealed by validating its oncogenes and tumor suppressor genes; however, the available data remain insufficient for medical workers to design effective treatments.

Large-scale identification of PC-related genes can promote studies on PC.

In this study, we propose a computational method for mining new candidate PC-related genes.

A large network was constructed using protein-protein interaction information, and a shortest path approach was applied to mine new candidate genes based on validated PC-related genes.

In addition, a permutation test was adopted to further select key candidate genes.

Finally, for all discovered candidate genes, the likelihood that the genes are novel PC-related genes is discussed based on their currently known functions.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yuan, Fei& Zhang, Yu-Hang& Wan, Sibao& Wang, ShaoPeng& Kong, Xiangyin. 2015. Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056165

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yuan, Fei…[et al.]. Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056165

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yuan, Fei& Zhang, Yu-Hang& Wan, Sibao& Wang, ShaoPeng& Kong, Xiangyin. Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056165

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1056165