Dexamethasone Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

المؤلفون المشاركون

Feng, Xinhong
Yuan, Wei

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-09

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Dexamethasone is currently used for the treatment of peripheral nerve injury, but its mechanisms of action are not completely understood.

Inflammation/immune response at the site of nerve lesion is known to be an essential trigger of the pathological changes that have a critical impact on nerve repair and regeneration.

In this study, we observed the effects of various doses of dexamethasone on the functional recovery after sciatic nerve crush injury in a rat model.

Motor functional recovery was monitored by walking track analysis and gastrocnemius muscle mass ratio.

The myelinated axon number was counted by morphometric analysis.

Rats administered dexamethasone by local intramuscular injection had a higher nerve function index value, increased gastrocnemius muscle mass ratio, reduced Wallerian degeneration severity, and enhanced regenerated myelinated nerve fibers.

Immunohistochemical analysis was performed for CD3 expression, which is a marker for T-cell activation, and infiltration in the sciatic nerve.

Dexamethasone-injected rats had fewer CD3-positive cells compared to controls.

Furthermore, we found increased expression of GAP-43, which is a factor associated with development and plasticity of the nervous system, in rat nerves receiving dexamethasone.

These results provide strong evidence that dexamethasone enhances sciatic nerve regeneration and function recovery in a rat model of sciatic nerve injury through immunosuppressive and potential neurotrophic effects.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Feng, Xinhong& Yuan, Wei. 2015. Dexamethasone Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056191

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Feng, Xinhong& Yuan, Wei. Dexamethasone Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056191

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Feng, Xinhong& Yuan, Wei. Dexamethasone Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056191

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1056191