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Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action
المؤلفون المشاركون
Rashid, Qudsia
Abid, Mohammad
Gupta, Neha
Tyagi, Tarun
Ashraf, Mohammad Z.
Jairajpuri, Mohamad Aman
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Physiological hemostatic balance is a coordinated outcome of counteracting coagulation and fibrinolytic systems.
An imbalance of procoagulant and anticoagulant factors may result in life threatening thromboembolism.
Presently, anticoagulant administration is the first line of therapy for the treatment of these conditions and several anticoagulants have been approved, including various forms of heparin.
However, the polyanionic nature and multispecificity of heparin pose several complications.
Generally, the polysulfated compounds with antithrombotic potential are thought to have feasible synthetic procedures with much less bleeding, thus having favourable safety profiles.
Here we report the synthesis of a novel compound, trehalose octasulfate and the assessment of its anticoagulation potential.
Molecular docking of trehalose and trehalose octasulfate with antithrombin showed a specificity switch in binding affinity on sulfation, where trehalose octasulfate interacts with critical residues of AT that are either directly involved in heparin binding or in the conformational rearrangement of AT on heparin binding.
An in vitro analysis of trehalose octasulfate demonstrated prolonged clotting time.
Lead compound when intravenously injected in occlusion induced thrombotic rats showed remarkable reduction in the size and weight of the clot at a low dose.
Delay in coagulation time was observed by analysing blood plasma isolated from rats preinjected with trehalose octasulfate.
A decrease in Adenosine 5′-Diphosphate (ADP) induced platelet aggregation indicated a probable dual anticoagulant and antiplatelet mechanism of action.
To summarize, this study presents trehalose octasulfate as a novel, effective, dual acting antithrombotic agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rashid, Qudsia& Abid, Mohammad& Gupta, Neha& Tyagi, Tarun& Ashraf, Mohammad Z.& Jairajpuri, Mohamad Aman. 2015. Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056207
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rashid, Qudsia…[et al.]. Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056207
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rashid, Qudsia& Abid, Mohammad& Gupta, Neha& Tyagi, Tarun& Ashraf, Mohammad Z.& Jairajpuri, Mohamad Aman. Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056207
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056207
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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