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Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury
المؤلفون المشاركون
Mizuno, Shugo
Kishiwada, Masashi
Kuriyama, Naohisa
Tanemura, Akihiro
Matsuda, Akitoshi
Kato, Hiroyuki
Murata, Yasuhiro
Isaji, Shuji
Sakurai, Hiroyuki
Azumi, Yoshinori
Usui, Masanobu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Activated protein C (APC) has cytoprotective effects on liver ischemia-reperfusion injury (IRI).
However, it is unclear whether APC is beneficial in steatotic liver IRI.
We compared the cytoprotective effects of APC in nonsteatotic and steatotic liver IRI.
Methods.
Mice fed either normal diets (ND mice) or high fat diets (HF mice), were treated with APC or saline (control) and were performed 60 min partial IRI.
Moreover, primary steatotic hepatocytes were either untreated or treated with APC and then incubated with H2O2.
Results.
APC significantly reduced serum transaminase levels and the inflammatory cells infiltration compared with control at 4 h in ND mice and at 24 h in HF mice.
APC inhibited sinusoidal endothelial injury in ND mice, but not in HF mice.
In contrast, APC activated adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in HF mice, but not in ND mice.
In the in vitro study, APC significantly increased AMPK phosphorylation, ATP concentration, and survival rates of hepatocytes compared with control.
Conclusion.
During IRI in normal liver, APC attenuated initial damage by inhibiting inflammatory cell infiltration and sinusoidal endothelial injury, but not in steatotic liver.
However, in steatotic liver, APC might attenuate late damage via activation of AMPK.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matsuda, Akitoshi& Kuriyama, Naohisa& Kato, Hiroyuki& Tanemura, Akihiro& Murata, Yasuhiro& Azumi, Yoshinori…[et al.]. 2015. Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matsuda, Akitoshi…[et al.]. Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matsuda, Akitoshi& Kuriyama, Naohisa& Kato, Hiroyuki& Tanemura, Akihiro& Murata, Yasuhiro& Azumi, Yoshinori…[et al.]. Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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