Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema
المؤلفون المشاركون
Hermanowicz, Adam
Reszec, Joanna
Chyczewski, Lech
Rutkowski, Robert
Turek, Grzegorz
Mariak, Zenon
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Meningiomas constitute up to 13% of all intracranial tumors.
The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome.
The aim of this study was to analyze the expressions of MMP-9 and VEGF in a group of meningiomas of various grades and to study associations between these two markers and PTBE.
The study included patients with supratentorial meningiomas.
The patients were divided into low- (G1) and high-grade meningiomas (G2 and G3).
PTBE was assessed on MRI.
The expressions of VEGF and MMP-9 were determined immunohistochemically.
The expression of MMP-9 was observed significantly more often in G3 meningiomas than in lower grade tumors.
The presence of stage II or III PTBE was associated with a significant increase in MMP-9 expression.
The expression of VEGF did not differ across the PTBE stages.
Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reszec, Joanna& Hermanowicz, Adam& Rutkowski, Robert& Turek, Grzegorz& Mariak, Zenon& Chyczewski, Lech. 2015. Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reszec, Joanna…[et al.]. Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reszec, Joanna& Hermanowicz, Adam& Rutkowski, Robert& Turek, Grzegorz& Mariak, Zenon& Chyczewski, Lech. Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر