Predictive Value of Interim PETCT in DLBCL Treated with R-CHOP: Meta-Analysis

الملخص EN

Objective.

We conducted a meta-analysis to evaluate the predictive value of interim 18F-FDG PET/CT in patients with DLBCL treated with R-CHOP chemotherapy.

Methods.

We searched for articles published in PubMed, ScienceDirect, Wiley, Scopus, and Ovid database from inception to March 2014.

Articles related to interim PET/CT in patients with DLBCL treated with R-CHOP chemotherapy were selected.

PFS with or without OS was chosen as the endpoint to evaluate the prognostic significance of interim PET/CT.

Results.

Six studies with a total of 605 cases were included.

The sensitivity of interim PET/CT ranged from 21.2% to 89.7%, and the pooled sensitivity was 52.4%.

The specificity of interim PET/CT ranged from 37.4% to 90.7%, and the pooled specificity was 67.8%.

The pooled positive likelihood ratio and negative likelihood ratio were 1.780 and 0.706, respectively.

The explained AUC was 0.6978 and the Q * was 0.6519.

Conclusions.

The sensitivity and specificity of interim PET/CT in predicting the outcome of DLBCL patients treated with R-CHOP chemotherapy were not satisfactory (52.4% and 67.8%, resp.).

To improve this, some more work should be done to unify the response criteria and some more research to assess the prognostic value of interim PET/CT with semiquantitative analysis.