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Investigating the Pretreatment miRNA Expression Patterns of Advanced Hepatocellular Carcinoma Patients in Association with Response to TACE Treatment
المؤلفون المشاركون
Ismail, Heba M. S.
El-Halawany, Medhat S.
Zeeneldin, Ahmed A.
Elfiky, Ammar
Tantawy, Marwa
Kobaisi, Mohamed H.
Hamed, Ikram
Abdel Wahab, Abdel Hady A.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options.
Transarterial chemoembolization (TACE) using chemotherapy agents—doxorubicin and cisplatin—is an accepted treatment option for locally advanced hepatocellular carcinoma.
In the current study, we analyzed the expression pattern of a selected panel of 94 miRNAs in archival samples that were collected prior to treatment from 15 Egyptian patients diagnosed with advanced hepatocelleular carcinoma.
We observed an overall increase in miRNA expression in HCC samples compared with normal subjects.
Out of 94 examined miRNAs, 53 were significantly upregulated while 3 miRNAs were downregulated in HCC samples compared to normal liver samples.
Comparing the pretreatment miRNA expression profiles in HCC patients and the patients response to TACE treatment resulted in the identification of a set of 12 miRNAs that are significantly upregulated in nonresponders group.
This miRNA panel includes miR-10a-1, miR-23a-1, miR-24, miR-26a, miR-27a, miR-30c, miR-30e, miR-106b, miR-133b, miR-199a, miR-199-3p, and miR-200b.
Furthermore, we observed that a panel of 10 miRNAs was significantly associated with patients’ survival status at 1 year.
These results highlight the potential implications of pretreatment miRNAs expression profiling in prediction of the patients’ response to TACE treatment in liver cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Halawany, Medhat S.& Ismail, Heba M. S.& Zeeneldin, Ahmed A.& Elfiky, Ammar& Tantawy, Marwa& Kobaisi, Mohamed H.…[et al.]. 2015. Investigating the Pretreatment miRNA Expression Patterns of Advanced Hepatocellular Carcinoma Patients in Association with Response to TACE Treatment. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Halawany, Medhat S.…[et al.]. Investigating the Pretreatment miRNA Expression Patterns of Advanced Hepatocellular Carcinoma Patients in Association with Response to TACE Treatment. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Halawany, Medhat S.& Ismail, Heba M. S.& Zeeneldin, Ahmed A.& Elfiky, Ammar& Tantawy, Marwa& Kobaisi, Mohamed H.…[et al.]. Investigating the Pretreatment miRNA Expression Patterns of Advanced Hepatocellular Carcinoma Patients in Association with Response to TACE Treatment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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