Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets
المؤلفون المشاركون
Li, Xiao-Hua
Zhao, Guo-Zhen
Qiu, Long-Xin
Dai, Ai-Ling
Wu, Wang-Wei
Yang, Xiao-Yan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Haemophilus parasuis can cause Glässer’s disease characterized by fibrinous polyserositis, polyarthritis, and meningitis.
The current prevention of Glässer’s disease is mainly based on the inactive vaccines; however, the protective efficacy usually fails in heterogeneous or homologous challenges.
Here, the predominant lineage of H.
parasuis (LY02 strain) in Fujian province, China, characterized as serovar 5, was used to evaluate the protective immunity against acute H.
parasuis infection in piglets after inactivation.
Following challenging with H.
parasuis, only mild lesions in the pigs immunized with the killed vaccine were observed, whereas the typical symptoms of Glässer’s disease presented in the nonimmunized piglets.
A strong IgG immune response was induced by the inactive vaccine.
CD4+ and CD8+ T lymphocyte levels were increased, indicating the potent cellular immune responses were elicited.
The significantly high levels of IL-2, IL-4, TGF-β, and IFN-γ in sera from pigs immunized with this killed vaccine suggested that the mixed Th1 and Th2 immune responses were induced, associated with the high protection against H.
parasuis infection compared to the nonimmunized animals.
This study indicated that the inactivated LY02 strain of H.
parasuis could serve as a potential vaccine candidate to prevent the prevalence of H.
parasuis in Fujian province, China.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao-Hua& Zhao, Guo-Zhen& Qiu, Long-Xin& Dai, Ai-Ling& Wu, Wang-Wei& Yang, Xiao-Yan. 2015. Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao-Hua…[et al.]. Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao-Hua& Zhao, Guo-Zhen& Qiu, Long-Xin& Dai, Ai-Ling& Wu, Wang-Wei& Yang, Xiao-Yan. Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر