A New Mechanism of Vitamin C Effects on AFM147(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice
المؤلفون المشاركون
Kurihara, Hiroshi
Tan, Rui-Rong
Tang, Lu-Ping
Cai, Ying
Li, Yi-Fang
Chen, Min
Chen, Huan
Chen, Xiao-Mei
He, Rong-Rong
Tsoi, Bun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
It is well known that vitamin C could protect against influenza infection, but little is known about the mechanisms.
This study aimed to investigate the influence and possible mechanisms of vitamin C on pneumonia induced by influenza virus in stressed mice.
Results showed that restraint stress significantly increased the mortality and the severity of pneumonia in mice caused by A/FM/1/47(H1N1) virus infection, which was attenuated by oral administration of vitamin C (125 and 250 mg/kg).
Moreover, vitamin C administration significantly decreased expression of susceptibility genes, including mitochondrial antiviral signaling (MAVS) and interferon regulatory factor 3 (IRF3), and increased expression of NF-κB.
These work in conjunction to induce type I interferons (IFNs) and elicit innate antiviral response as key factors in RIG-I-mediated signal transduction pathway.
The above effects of vitamin C were further found to relate with inhibition of excess CORT synthesis by regulating steroid hydroxylating enzymes in adrenal gland.
In conclusion, the protective effects of vitamin C on influenza virus-caused pneumonia might be related to its inhibition of CORT synthesis, which reduces the susceptibility to influenza viral infection in restraint-stressed mice.
These findings provide a new mechanism for the effects of vitamin C on influenza virus-induced pneumonia in restraint-stressed mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Ying& Li, Yi-Fang& Tang, Lu-Ping& Tsoi, Bun& Chen, Min& Chen, Huan…[et al.]. 2015. A New Mechanism of Vitamin C Effects on AFM147(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Ying…[et al.]. A New Mechanism of Vitamin C Effects on AFM147(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Ying& Li, Yi-Fang& Tang, Lu-Ping& Tsoi, Bun& Chen, Min& Chen, Huan…[et al.]. A New Mechanism of Vitamin C Effects on AFM147(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر