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CD40 Ligand Deficient C57BL6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens
المؤلفون المشاركون
Estrada-Parra, Sergio
Lopez-Saucedo, Catalina
Bernal-Reynaga, Rodolfo
Zayas-Jahuey, Jesus
Galindo-Gomez, Silvia
Garcia-Galvez, Carlos
Estrada-Garcia, Teresa
Shibayama, Mineko
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Individuals with X-HIGM syndrome fail to express functional CD40 ligand; consequently they cannot mount effective protective antibody responses against pathogenic bacteria.
We evaluated, compared, and characterized the humoral immune response of wild type (WT) and C57-CD40L deficient (C57-CD40L−/−) mice infected with Citrobacter rodentium.
Basal serum isotype levels were similar for IgM and IgG3 among mice, while total IgG and IgG2b concentrations were significantly lower in C57-CD40L−/− mice compared with WT.
Essentially IgG1 and IgG2c levels were detectable only in WT mice.
C57-CD40L−/− animals, orally inoculated with 2×109 CFU, presented several clinical manifestations since the second week of infection and eventually died.
In contrast at this time point no clinical manifestations were observed among C57-CD40L−/− mice infected with 1×107 CFU.
Infection was subclinical in WT mice inoculated with either bacterial dose.
The serum samples from infected mice (1×107 CFU), collected at day 14 after infection, had similar C.
rodentium-specific IgM titres.
Although C57-CD40L−/− animals had lower IgG and IgG2b titres than WT mice, C57-CD40L−/− mice sera displayed complement-mediated bactericidal activity against C.
rodentium.
C.
rodentium-infected C57-CD40L−/− mice are capable of producing antibodies that are protective.
C57-CD40L−/− mouse is a useful surrogate model of X-HIGM syndrome for studying immune responses elicited against pathogens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lopez-Saucedo, Catalina& Bernal-Reynaga, Rodolfo& Zayas-Jahuey, Jesus& Galindo-Gomez, Silvia& Shibayama, Mineko& Garcia-Galvez, Carlos…[et al.]. 2015. CD40 Ligand Deficient C57BL6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lopez-Saucedo, Catalina…[et al.]. CD40 Ligand Deficient C57BL6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lopez-Saucedo, Catalina& Bernal-Reynaga, Rodolfo& Zayas-Jahuey, Jesus& Galindo-Gomez, Silvia& Shibayama, Mineko& Garcia-Galvez, Carlos…[et al.]. CD40 Ligand Deficient C57BL6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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