Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson’s Disease
المؤلفون المشاركون
Luo, ChunYan
Guo, XiaoYan
Song, Wei
Zhao, Bi
Cao, Bei
Yang, Jing
Gong, QiYong
Shang, Hui-Fang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson’s disease (PD).
However, little is known about the inter-hemispheric interaction in PD.
Methods.
Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans.
We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach.
Then, we correlated the results from VMHC and clinical features in PD patients.
Results.
Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD.
In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.
Conclusions.
Our results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, ChunYan& Guo, XiaoYan& Song, Wei& Zhao, Bi& Cao, Bei& Yang, Jing…[et al.]. 2015. Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056406
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, ChunYan…[et al.]. Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson’s Disease. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056406
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, ChunYan& Guo, XiaoYan& Song, Wei& Zhao, Bi& Cao, Bei& Yang, Jing…[et al.]. Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056406
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056406
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر