Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage
المؤلفون المشاركون
Halaby, Marie-Jo
Li, Yan
Harris, Benjamin R.
Jiang, Shuxia
Miskimins, W. Keith
Yang, Da-Qing
Cleary, Margot P.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Synthesis of the p53 tumor suppressor increases following DNA damage.
This increase and subsequent activation of p53 are essential for the protection of normal cells against tumorigenesis.
We previously discovered an internal ribosome entry site (IRES) that is located at the 5′-untranslated region (UTR) of p53 mRNA and found that the IRES activity increases following DNA damage.
However, the mechanism underlying IRES-mediated p53 translation in response to DNA damage is still poorly understood.
In this study, we discovered that translational control protein 80 (TCP80) has increased binding to the p53 mRNA in vivo following DNA damage.
Overexpression of TCP80 also leads to increased p53 IRES activity in response to DNA damage.
TCP80 has increased association with RNA helicase A (RHA) following DNA damage and overexpression of TCP80, along with RHA, leads to enhanced expression of p53.
Moreover, we found that MCF-7 breast cancer cells with decreased expression of TCP80 and RHA exhibit defective p53 induction following DNA damage and diminished expression of its downstream target PUMA, a proapoptotic protein.
Taken together, our discovery of the function of TCP80 and RHA in regulating p53 IRES and p53 induction following DNA damage provides a better understanding of the mechanisms that regulate IRES-mediated p53 translation in response to genotoxic stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Halaby, Marie-Jo& Li, Yan& Harris, Benjamin R.& Jiang, Shuxia& Miskimins, W. Keith& Cleary, Margot P.…[et al.]. 2015. Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Halaby, Marie-Jo…[et al.]. Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Halaby, Marie-Jo& Li, Yan& Harris, Benjamin R.& Jiang, Shuxia& Miskimins, W. Keith& Cleary, Margot P.…[et al.]. Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر