MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes
المؤلفون المشاركون
Wei, Jeanne Y.
Zhang, Xiaomin
Azhar, Gohar
Williams, Emmanuel D.
Rogers, Steven C.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The microRNAs and microRNA clusters have been implicated in normal cardiac development and also disease, including cardiac hypertrophy, cardiomyopathy, heart failure, and arrhythmias.
Since a microRNA cluster has from two to dozens of microRNAs, the expression of a microRNA cluster could have a substantial impact on its target genes.
In the present study, the configuration and distribution of microRNA clusters in the mouse genome were examined at various inter-microRNA distances.
Three important microRNA clusters that are significantly impacted during adult cardiac aging, the miR-17-92, miR-106a-363, and miR-106b-25, were also examined in terms of their genomic location, RNA transcript character, sequence homology, and their relationship with the corresponding microRNA families.
Multiple microRNAs derived from the three clusters potentially target various protein components of the cdc42-SRF signaling pathway, which regulates cytoskeleton dynamics associated with cardiac structure and function.
The data indicate that aging impacted the expression of both guide and passenger strands of the microRNA clusters; nutrient stress also affected the expression of the three microRNA clusters.
The miR-17-92, miR-106a-363, and miR-106b-25 clusters are likely to impact the Cdc42-SRF signaling pathway and thereby affect cardiac morphology and function during pathological conditions and the aging process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xiaomin& Azhar, Gohar& Williams, Emmanuel D.& Rogers, Steven C.& Wei, Jeanne Y.. 2015. MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xiaomin…[et al.]. MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xiaomin& Azhar, Gohar& Williams, Emmanuel D.& Rogers, Steven C.& Wei, Jeanne Y.. MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر