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Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro
المؤلفون المشاركون
Marzi, Ingo
Kontradowitz, K.
Oppermann, Elsie
Verboket, René
Schaible, Alexander
Brune, Jan C.
Nau, Christoph
Meier, Simon
Henrich, Dirk
Seebach, Caroline
Bonig, Halvard
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Bone marrow mononuclear cells (BMCs) are suitable for bone tissue engineering.
Comparative data regarding the needs of BMC for the adhesion on biomaterials and biocompatibility to various biomaterials are lacking to a large extent.
Therefore, we evaluated whether a surface coating would enhance BMC adhesion and analyze the biocompatibility of three different kinds of biomaterials.
BMCs were purified from human bone marrow aspirate samples.
Beta tricalcium phosphate (β-TCP, without coating or coated with fibronectin or human plasma), demineralized bone matrix (DBM), and bovine cancellous bone (BS) were assessed.
Seeding efficacy on β-TCP was 95% regardless of the surface coating.
BMC demonstrated a significantly increased initial adhesion on DBM and β-TCP compared to BS.
On day 14, metabolic activity was significantly increased in BMC seeded on DBM in comparison to BMC seeded on BS.
Likewise increased VEGF-synthesis was observed on day 2 in BMC seeded on DBM when compared to BMC seeded on BS.
The seeding efficacy of BMC on uncoated biomaterials is generally high although there are differences between these biomaterials.
Beta-TCP and DBM were similar and both superior to BS, suggesting either as suitable materials for spatial restriction of BMC used for regenerative medicine purposes in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Henrich, Dirk& Verboket, René& Schaible, Alexander& Kontradowitz, K.& Oppermann, Elsie& Brune, Jan C.…[et al.]. 2015. Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Henrich, Dirk…[et al.]. Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Henrich, Dirk& Verboket, René& Schaible, Alexander& Kontradowitz, K.& Oppermann, Elsie& Brune, Jan C.…[et al.]. Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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