Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View
المؤلفون المشاركون
Glukhov, Alexey V.
Miragoli, Michele
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-01
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of interstitial myofibroblasts.
These cells are responsible for the uncontrolled deposition of the extracellular matrix, which pathologically separate cardiomyocyte bundles.
The enhanced fibrosis is thought to contribute to arrhythmias “indirectly” because a collagenous septum is a passive substrate for propagation, resulting in impulse conduction block and/or zigzag conduction.
However, the emerging results demonstrate that myofibroblasts in vitro also promote arrhythmogenesis due to direct implications upon cardiomyocyte electrophysiology.
This electrical interference may be considered beneficial as it resolves any conduction blocks; however, the passive properties of myofibroblasts might cause a delay in impulse propagation, thus promoting AF due to discontinuous slow conduction.
Moreover, low-polarized myofibroblasts reduce, via cell-density dependence, the fast driving inward current for cardiac impulse conduction, therefore resulting in arrhythmogenic uniformly slow propagation.
Critically, the subsequent reduction in cardiomyocytes resting membrane potential in vitro significantly increases the likelihood of ectopic activity.
Myofibroblast densities and the degree of coupling at cellular border zones also impact upon this likelihood.
By considering future in vivo studies, which identify myofibroblasts “per se” as a novel targets for cardiac arrhythmias, this review aims to describe the implications of noncardiomyocyte view in the context of AF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miragoli, Michele& Glukhov, Alexey V.. 2015. Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miragoli, Michele& Glukhov, Alexey V.. Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1056773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miragoli, Michele& Glukhov, Alexey V.. Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر