Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description
المؤلفون المشاركون
De Sá Júnior, Paulo Luiz
Carvalho, R. F.
Beçak, W.
Araldi, R. P.
Mazzuchelli-de-Souza, Jacqueline
Modolo, Diego Grando
Souza, Edislane Barreiros de
Melo, Thatiana Corrêa de
Spadacci-Morena, Diva Denelle
Magnelli, Roberta Fiusa
Carvalho, Márcio Augusto Caldas Rocha de
Stocco, Rita de Cassia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Bovine papillomavirus (BPV) is considered a useful model to study HPV oncogenic process.
BPV interacts with the host chromatin, resulting in DNA damage, which is attributed to E5, E6, and E7 viral oncoproteins activity.
However, the oncogenic mechanisms of BPV E6 oncoprotein per se remain unknown.
This study aimed to evaluate the mutagenic potential of Bos taurus papillomavirus type 1 (BPV-1) E6 recombinant oncoprotein by the cytokinesis-block micronucleus assay (CBMNA) and comet assay (CA).
Peripheral blood samples of five calves were collected.
Samples were subjected to molecular diagnosis, which did not reveal presence of BPV sequences.
Samples were treated with 1 μg/mL of BPV-1 E6 oncoprotein and 50 μg/mL of cyclophosphamide (positive control).
Negative controls were not submitted to any treatment.
The samples were submitted to the CBMNA and CA.
The results showed that BPV E6 oncoprotein induces clastogenesis per se, which is indicative of genomic instability.
These results allowed better understanding the mechanism of cancer promotion associated with the BPV E6 oncoprotein and revealed that this oncoprotein can induce carcinogenesis per se.
E6 recombinant oncoprotein has been suggested as a possible vaccine candidate.
Results pointed out that BPV E6 recombinant oncoprotein modifications are required to use it as vaccine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Araldi, R. P.& Mazzuchelli-de-Souza, Jacqueline& Modolo, Diego Grando& Souza, Edislane Barreiros de& Melo, Thatiana Corrêa de& Spadacci-Morena, Diva Denelle…[et al.]. 2015. Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Araldi, R. P.…[et al.]. Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Araldi, R. P.& Mazzuchelli-de-Souza, Jacqueline& Modolo, Diego Grando& Souza, Edislane Barreiros de& Melo, Thatiana Corrêa de& Spadacci-Morena, Diva Denelle…[et al.]. Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر