Phytochemical Analysis and Modulation of Antibiotic Activity by Luehea paniculata Mart. & Zucc. (Malvaceae) in Multiresistant Clinical Isolates of Candida Spp.
المؤلفون المشاركون
Douglas Melo Coutinho, Henrique
Braga, Maria F. B. M.
Calixto Júnior, João T.
Morais, Selene M.
Martins, Clécio G.
Vieira, Larissa G.
Carneiro, Joara N. P.
Machado, Antonio J. P.
Tintino, Saulo R.
de Menezes, Irwin Rose Alencar
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The high incidence of fungal infections has led to the continuous search for new drugs.
Extracts of Luehea paniculata, a tree of multiple medicinal uses, were evaluated for anti-Candida activity, as well as its modulator potential of the Fluconazole antibiotic.
Chemical prospecting of ethanol extracts of leaf and bark was carried out, the quantification of total phenols and flavonoids, characterized by the HPLC-DAD technique.
The rosmarinic acid and the vitexin flavonoid were observed as major constituents in ELELP and ESWELP, respectively.
Antioxidant activity was also evaluated by the method of scavenging the free radical DPPH, and quercetin was used as standard, obtaining IC50 values: 0.341 (mg/mL) for ELELP and 0.235 (mg/mL) for ESWELP.
The microdilution assay was performed for antifungal activity against strains of Candida albicans, C.
krusei, and C.
tropicalis and showed minimum inhibitory concentrations values ≥1024 μg/mL.
In the modulator action of extracts on Fluconazole against multiresistant clinical isolates of Candida (subinhibitory concentration minimum of 128 μg/mL), a significant synergism was observed, indicating that the extracts potentiated the antifungal effect against C.
tropicalis, where antioxidant flavonoids could be responsible.
This is the first report about modifying activity of the antibiotic action of a species of the genus Luehea.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calixto Júnior, João T.& Morais, Selene M.& Martins, Clécio G.& Vieira, Larissa G.& Braga, Maria F. B. M.& Carneiro, Joara N. P.…[et al.]. 2015. Phytochemical Analysis and Modulation of Antibiotic Activity by Luehea paniculata Mart. & Zucc. (Malvaceae) in Multiresistant Clinical Isolates of Candida Spp.. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calixto Júnior, João T.…[et al.]. Phytochemical Analysis and Modulation of Antibiotic Activity by Luehea paniculata Mart. & Zucc. (Malvaceae) in Multiresistant Clinical Isolates of Candida Spp.. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calixto Júnior, João T.& Morais, Selene M.& Martins, Clécio G.& Vieira, Larissa G.& Braga, Maria F. B. M.& Carneiro, Joara N. P.…[et al.]. Phytochemical Analysis and Modulation of Antibiotic Activity by Luehea paniculata Mart. & Zucc. (Malvaceae) in Multiresistant Clinical Isolates of Candida Spp.. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر