The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis
المؤلفون المشاركون
Dimova, Rumyana
Tankova, Tsvetalina
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In recent years, most research efforts have been focused on studying insulin-sensitizing adipokines.
One of the most recently discovered adipokines is vaspin, a visceral adipose tissue-derived serine protease inhibitor.
Vaspin levels have been found significantly increased in mice with obesity and insulin resistance.
It has been assumed that vaspin serves as an insulin sensitizer with anti-inflammatory effects and might act as a compensatory mechanism in response to decreased insulin sensitivity.
Most studies in humans have shown a positive correlation between vaspin gene expression and serum levels, and metabolic syndrome parameters.
Vaspin gene expression is influenced by age and gender, and the administration of insulin sensitizers enhances it in mice, whereas the use of metformin decreases serum vaspin levels in humans, probably due to different regulatory mechanisms.
Presumably vaspin plays local and endocrine role in the development of initial and advanced atherosclerosis in obese subjects and might be used as a predictor of coronary and cerebrovascular disease.
It is believed that vaspin could be regarded as a new link between obesity and related metabolic disorders, including glucose intolerance.
The entire understanding of vaspin intimate mechanism of action might enable the development of novel etiology-based treatment strategies, targeting metabolic and glucose tolerance disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dimova, Rumyana& Tankova, Tsvetalina. 2015. The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dimova, Rumyana& Tankova, Tsvetalina. The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dimova, Rumyana& Tankova, Tsvetalina. The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر