Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study
المؤلفون المشاركون
Laske, Christoph
Saykin, Andrew J.
Sohrabi, Hamid R.
Jasielec, Mateusz S.
Müller, Stephan
Förster, Stefan
Drzezga, Alexander
Mueller-Sarnowski, Felix
Danek, Adrian
Jucker, Mathias
Bateman, Randall J.
Buckles, Virginia
Martins, Ralph N.
Morris, John C.
Dominantly Inherited Alzheimer Network (DIAN), John C.
Köhler, Niklas
Graeber, Susanne
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer’s disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN).
Methods.
The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107 ; NCs: n = 109 ), early symptomatic (CDR 0.5; MCs: n = 48 ; NCs: n = 8 ), and dementia stage (CDR ≥ 1; MCs: n = 28 ; NCs: n = 0 ).
These groups were subdivided by the presence or absence of SMCs.
Results.
At CDR 0, SMCs were present in 12.1% of MCs and 9.2% of NCs ( P = 0.6 ) .
At CDR 0.5, SMCs were present in 66.7% of MCs and 62.5% of NCs ( P = 1.0 ) .
At CDR ≥ 1, SMCs were present in 96.4% of MCs.
SMCs in MCs were significantly associated with CDR, logical memory scores, Geriatric Depression Scale, education, and estimated years to onset.
Conclusions.
The present study shows that SMCs assessed by a single-item scale have no diagnostic value to identify preclinical ADAD in asymptomatic individuals.
These results demonstrate the need of further improvement of SMC measures that should be examined in large clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laske, Christoph& Sohrabi, Hamid R.& Jasielec, Mateusz S.& Müller, Stephan& Köhler, Niklas& Graeber, Susanne…[et al.]. 2015. Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laske, Christoph…[et al.]. Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laske, Christoph& Sohrabi, Hamid R.& Jasielec, Mateusz S.& Müller, Stephan& Köhler, Niklas& Graeber, Susanne…[et al.]. Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر