A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method
المؤلفون المشاركون
Ye, Jianqiao
Brocklehurst, Paul
Adeniran, Ismail
Yang, Dongmin
Sheng, Yong
Zhang, Henggui
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cardiac tissue is a syncytium of coupled cells with pronounced intrinsic discrete nature.
Previous models of cardiac electromechanics often ignore such discrete properties and treat cardiac tissue as a continuous medium, which has fundamental limitations.
In the present study, we introduce a 2D electromechanical model for human atrial tissue based on the discrete element method (DEM).
In the model, single-cell dynamics are governed by strongly coupling the electrophysiological model of Courtemanche et al.
to the myofilament model of Rice et al.
with two-way feedbacks.
Each cell is treated as a viscoelastic body, which is physically represented by a clump of nine particles.
Cell aggregations are arranged so that the anisotropic nature of cardiac tissue due to fibre orientations can be modelled.
Each cell is electrically coupled to neighbouring cells, allowing excitation waves to propagate through the tissue.
Cell-to-cell mechanical interactions are modelled using a linear contact bond model in DEM.
By coupling cardiac electrophysiology with mechanics via the intracellular Ca2+ concentration, the DEM model successfully simulates the conduction of cardiac electrical waves and the tissue’s corresponding mechanical contractions.
The developed DEM model is numerically stable and provides a powerful method for studying the electromechanical coupling problem in the heart.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brocklehurst, Paul& Adeniran, Ismail& Yang, Dongmin& Sheng, Yong& Zhang, Henggui& Ye, Jianqiao. 2015. A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brocklehurst, Paul…[et al.]. A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brocklehurst, Paul& Adeniran, Ismail& Yang, Dongmin& Sheng, Yong& Zhang, Henggui& Ye, Jianqiao. A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر