![](/images/graphics-bg.png)
Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling
المؤلفون المشاركون
Huang, Chia-Wei
Huang, Chao-Ching
Chen, Yuh-Ling
Fan, Shih-Chen
Hsueh, Yuan-Yu
Ho, Chien-Jung
Wu, Chia-Ching
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Neonatal hypoxic-ischemic (HI) brain injuries disrupt the integrity of neurovascular structure and lead to lifelong neurological deficit.
The devastating damage can be ameliorated by preserving the endothelial network, but the source for therapeutic cells is limited.
We aim to evaluate the beneficial effect of mechanical shear stress in the differentiation of endothelial lineage cells (ELCs) from adipose-derived stem cells (ASCs) and the possible intracellular signals to protect HI injury using cell-based therapy in the neonatal rats.
The ASCs expressed early endothelial markers after biochemical stimulation of endothelial growth medium.
The ELCs with full endothelial characteristics were accomplished after a subsequential shear stress application for 24 hours.
When comparing the therapeutic potential of ASCs and ELCs, the ELCs treatment significantly reduced the infarction area and preserved neurovascular architecture in HI injured brain.
The transplanted ELCs can migrate and engraft into the brain tissue, especially in vessels, where they promoted the angiogenesis.
The activation of Akt by neuropilin 1 (NRP1) and vascular endothelial growth factor receptor 2 (VEGFR2) was important for ELC migration and following in vivo therapeutic outcomes.
Therefore, the current study demonstrated importance of mechanical factor in stem cell differentiation and showed promising protection of brain from HI injury using ELCs treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Chia-Wei& Huang, Chao-Ching& Chen, Yuh-Ling& Fan, Shih-Chen& Hsueh, Yuan-Yu& Ho, Chien-Jung…[et al.]. 2015. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Chia-Wei…[et al.]. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Chia-Wei& Huang, Chao-Ching& Chen, Yuh-Ling& Fan, Shih-Chen& Hsueh, Yuan-Yu& Ho, Chien-Jung…[et al.]. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)