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Emergence of Carbapenem-Resistant Klebsiella pneumoniae: Progressive Spread and Four-Year Period of Observation in a Cardiac Surgery Division
المؤلفون المشاركون
Valaperta, Rea
Lombardi, Fortunata
Colombo, Alessio
Valisi, Massimiliano
Costa, Elena
Gaia, Paola
Cornetta, Maria
Tejada, Milvana Rosa
Di Girolamo, Luca
Moroni, Alessandra
Ramundo, Federica
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Frequent use of carbapenems has contributed to the increase to K.
pneumoniae strains resistant to this class of antibiotics (CRKP), causing a problem in the clinical treatment of patients.
This investigation reports the epidemiology, genetic diversity, and clinical implication of the resistance to drugs mediated by CRKP in our hospital.
A total of 280 K.
pneumoniae strains were collected; in particular 98/280 (35%) were CRKP.
Sequencing analysis of CRKP isolated strains showed that 9/98 of MBL-producing strains carried the blaVIM-1 gene and 89/98 of the isolates were positive for blaKPC-2.
Antimicrobial susceptibility tests revealed a complete resistance to third-generation cephalosporins and a moderate resistance to tigecycline, gentamicin, and fluoroquinolones with percentages of resistance of 61%, 64%, and 98%, respectively.
A resistance of 31% was shown towards trimethoprim-sulfamethoxazole.
Colistin was the most active agent against CRKP with 99% of susceptibility.
Clonality was evaluated by PFGE and MLST: MLST showed the same clonal type, ST258, while PFGE analysis indicated the presence of a major clone, namely, pulsotype A.
This finding indicates that the prevalent resistant isolates were genetically related, suggesting that the spread of these genes could be due to clonal dissemination as well as to genetic exchange between different clones.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lombardi, Fortunata& Gaia, Paola& Valaperta, Rea& Cornetta, Maria& Tejada, Milvana Rosa& Di Girolamo, Luca…[et al.]. 2015. Emergence of Carbapenem-Resistant Klebsiella pneumoniae: Progressive Spread and Four-Year Period of Observation in a Cardiac Surgery Division. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lombardi, Fortunata…[et al.]. Emergence of Carbapenem-Resistant Klebsiella pneumoniae: Progressive Spread and Four-Year Period of Observation in a Cardiac Surgery Division. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lombardi, Fortunata& Gaia, Paola& Valaperta, Rea& Cornetta, Maria& Tejada, Milvana Rosa& Di Girolamo, Luca…[et al.]. Emergence of Carbapenem-Resistant Klebsiella pneumoniae: Progressive Spread and Four-Year Period of Observation in a Cardiac Surgery Division. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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