Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells
المؤلفون المشاركون
Arai, Yoshikazu
Hayakawa, Koji
Arai, Daisuke
Ito, Rie
Iwasaki, Yusuke
Saito, Koichi
Akutsu, Kazuhiko
Takatori, Satoshi
Ishii, Rie
Hayashi, Rumiko
Izumi, Shun-Ichiro
Kondo, Fumio
Horie, Masakazu
Nakazawa, Hiroyuki
Makino, Tsunehisa
Hirosawa, Mitsuko
Shiota, Kunio
Ohgane, Jun
Sugino, N.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The regulation of transcription and genome stability by epigenetic systems are crucial for the proper development of mammalian embryos.
Chemicals that disturb epigenetic systems are termed epimutagens.
We previously performed chemical screening that focused on heterochromatin formation and DNA methylation status in mouse embryonic stem cells and identified five epimutagens: diethyl phosphate (DEP), mercury (Hg), cotinine, selenium (Se), and octachlorodipropyl ether (S-421).
Here, we used human induced pluripotent stem cells (hiPSCs) to confirm the effects of 20 chemicals, including the five epimutagens, detected at low concentrations in maternal peripheral and cord blood samples.
Of note, these individual chemicals did not exhibit epimutagenic activity in hiPSCs.
However, because the fetal environment contains various chemicals, we evaluated the effects of combined exposure to chemicals (DEP, Hg, cotinine, Se, and S-421) on hiPSCs.
The combined exposure caused a decrease in the number of heterochromatin signals and aberrant DNA methylation status at multiple gene loci in hiPSCs.
The combined exposure also affected embryoid body formation and neural differentiation from hiPSCs.
Therefore, DEP, Hg, cotinine, Se, and S-421 were defined as an “epimutagen combination” that is effective at low concentrations as detected in maternal peripheral and cord blood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arai, Yoshikazu& Hayakawa, Koji& Arai, Daisuke& Ito, Rie& Iwasaki, Yusuke& Saito, Koichi…[et al.]. 2015. Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arai, Yoshikazu…[et al.]. Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1057109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arai, Yoshikazu& Hayakawa, Koji& Arai, Daisuke& Ito, Rie& Iwasaki, Yusuke& Saito, Koichi…[et al.]. Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر