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Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis
المؤلفون المشاركون
Bazmara, Hossein
Soltani, M.
Sefidgar, Mostafa
Bazargan, Majid
Naeenian, Mojtaba Mousavi
Elkamel, Ali
Raahemifar, Kaamran
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tumor-induced angiogenesis is the bridge between avascular and vascular tumor growth phases.
In tumor-induced angiogenesis, endothelial cells start to migrate and proliferate toward the tumor and build new capillaries toward the tumor.
There are two stages for sprout extension during angiogenesis.
The first stage is prior to anastomosis, when single sprouts extend.
The second stage is after anastomosis when closed flow pathways or loops are formed and blood flows in the closed loops.
Prior to anastomosis, biochemical and biomechanical signals from extracellular matrix regulate endothelial cell phenotype; however, after anastomosis, blood flow is the main regulator of endothelial cell phenotype.
In this study, the critical signaling pathways of each stage are introduced.
A Boolean network model is used to map environmental and flow induced signals to endothelial cell phenotype (proliferation, migration, apoptosis, and lumen formation).
Using the Boolean network model, blockade of intracellular signaling molecules of endothelial cell is investigated prior to and after anastomosis and the cell fate is obtained in each case.
Activation of apoptotic signal in endothelial cell can prevent the extension of new vessels and may inhibit angiogenesis.
It is shown that blockade of a few signaling molecules in endothelial cell activates apoptotic signal that are proposed as antiangiogenic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bazmara, Hossein& Soltani, M.& Raahemifar, Kaamran& Sefidgar, Mostafa& Bazargan, Majid& Naeenian, Mojtaba Mousavi…[et al.]. 2015. Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057194
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bazmara, Hossein…[et al.]. Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057194
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bazmara, Hossein& Soltani, M.& Raahemifar, Kaamran& Sefidgar, Mostafa& Bazargan, Majid& Naeenian, Mojtaba Mousavi…[et al.]. Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057194
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057194
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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