Metabolism of Albumin after Continuous Venovenous Hemofiltration in Patients with Systemic Inflammatory Response Syndrome
المؤلفون المشاركون
Chen, Yu
Ren, Jianan
Li, Jieshou
Qin, Xiaodong
Li, Guanwei
Zhou, Bo
Gu, Guosheng
Aa, JiYe
Hong, Zhiwu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The systemic inflammatory response syndrome (SIRS) is characterized by a hypercatabolic state induced by inflammatory mediators.
Continuous venovenous hemofiltration (CVVH) stabilizes the internal environment but also aggravates loss of amino acids.
The effect of CVVH on protein dynamics is largely unknown.
We adopted the stable isotopic tracer technology to investigate how CVVH changed serum albumin metabolism.
Methods.
Twenty SIRS patients were randomized into low- (2000 mL/h) and high- (4000 mL/h) volume CVVH groups according to the rate of replacement fluid.
Eight patients with abdominal infection matched for age, sex, and laboratory index served as controls.
Consecutive arterial blood samples were drawn during a primed-constant infusion of two stable isotopes to determine the albumin fractional synthesis rate (FSR) and fractional breakdown rate (FBR).
Results.
Before treatment, there was no significant difference of FSR and FBR among 3 groups.
After CVVH, the albumin FSR in high- and low-volume groups was 7.75 ± 1.08% and 7.30 ± 0.89%, respectively, both higher than in the control (5.83 ± 0.94%).
There was no significant difference in albumin FBR after treatment.
Conclusions.
Protein dynamic indicators could reflect protein synthesis and breakdown state directly and effectively.
CVVH increased albumin synthesis, while the breakdown rate remained at a high level independently of the CVVH rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yu& Ren, Jianan& Qin, Xiaodong& Li, Guanwei& Zhou, Bo& Gu, Guosheng…[et al.]. 2015. Metabolism of Albumin after Continuous Venovenous Hemofiltration in Patients with Systemic Inflammatory Response Syndrome. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yu…[et al.]. Metabolism of Albumin after Continuous Venovenous Hemofiltration in Patients with Systemic Inflammatory Response Syndrome. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yu& Ren, Jianan& Qin, Xiaodong& Li, Guanwei& Zhou, Bo& Gu, Guosheng…[et al.]. Metabolism of Albumin after Continuous Venovenous Hemofiltration in Patients with Systemic Inflammatory Response Syndrome. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر