Somatostatin Receptor Based Imaging and Radionuclide Therapy

المؤلفون المشاركون

Xu, Caiyun
Zhang, Hong

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-24

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors.

Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs.

Most neuroendocrine tumors (NETs) have high expression levels of SSTRs, which opens the possibility for tumor imaging and therapy with radiolabeled SST analogs.

A number of tracers have been developed for the diagnosis, staging, and treatment of NETs with impressive results, which facilitates the applications of human SSTR subtype 2 (hSSTr2) reporter gene based imaging and therapy in SSTR negative or weakly positive tumors to provide a novel approach for the management of tumors.

The hSSTr2 gene can act as not only a reporter gene for in vivo imaging, but also a therapeutic gene for local radionuclide therapy.

Even a second therapeutic gene can be transfected into the same tumor cells together with hSSTr2 reporter gene to obtain a synergistic therapeutic effect.

However, additional preclinical and especially translational and clinical researches are needed to confirm the value of hSSTr2 reporter gene based imaging and therapy in tumors.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Caiyun& Zhang, Hong. 2015. Somatostatin Receptor Based Imaging and Radionuclide Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1057235

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Caiyun& Zhang, Hong. Somatostatin Receptor Based Imaging and Radionuclide Therapy. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1057235

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Caiyun& Zhang, Hong. Somatostatin Receptor Based Imaging and Radionuclide Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1057235

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1057235