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Resveratrol Prevents Cardiovascular Complications in the SHRSTZ Rat by Reductions in Oxidative Stress and Inflammation
المؤلفون المشاركون
Pullen, Candice
Vella, Rebecca K.
Fenning, Andrew
Coulson, Fiona R.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The cardioprotective effects of resveratrol are well established in animal models of metabolic disease but are yet to be investigated in a combined model of hypertension and diabetes.
This study investigated the ability of resveratrol’s antioxidant and anti-inflammatory effects to prevent cardiovascular complications in the spontaneously hypertensive streptozotocin-induced diabetic rat.
Diabetes was induced in eight-week-old male spontaneously hypertensive rats via a single intravenous injection of streptozotocin.
Following this, resveratrol was administered orally for an eight-week period until the animals were sixteen weeks of age.
Upon completion of the treatment regime assessments of oxidative stress, lipid peroxidation, inflammation, and cardiovascular function were made.
Resveratrol administration to hypertensive-diabetic animals did not impact upon blood glucose or haemodynamics but significantly reduced oxidative stress, lipid peroxidation, and inflammatory cytokines.
Reductions in systemic levels of oxidative stress and inflammation conferred improvements in vascular reactivity and left ventricular pump function and electrophysiology.
This study demonstrates that resveratrol administration to hypertensive diabetic animals can elicit cardioprotective properties via antioxidant and anti-inflammatory effects.
The observed preservation of cardiovascular function was independent of changes in blood glucose concentration and haemodynamics, suggesting that oxidative stress and inflammation are key components within the pathological cascade associated with hypertension and diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vella, Rebecca K.& Pullen, Candice& Coulson, Fiona R.& Fenning, Andrew. 2015. Resveratrol Prevents Cardiovascular Complications in the SHRSTZ Rat by Reductions in Oxidative Stress and Inflammation. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057238
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vella, Rebecca K.…[et al.]. Resveratrol Prevents Cardiovascular Complications in the SHRSTZ Rat by Reductions in Oxidative Stress and Inflammation. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057238
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vella, Rebecca K.& Pullen, Candice& Coulson, Fiona R.& Fenning, Andrew. Resveratrol Prevents Cardiovascular Complications in the SHRSTZ Rat by Reductions in Oxidative Stress and Inflammation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057238
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057238
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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