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Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis
المؤلفون المشاركون
Wang, Cheng-Di
Chen, Nan
Huang, Lin
Wang, Jia-Rong
Chen, Zhi-Yuan
Jiang, Ya-Mei
He, Ya-Zhou
Ji, Yu-Lin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Several studies have evaluated the association between CYP1A1 polymorphisms and the susceptibility of chronic obstructive pulmonary disease (COPD) with inconclusive results.
We performed the first comprehensive meta-analysis to summarize the association between CYP1A1 polymorphisms and COPD risk.
Method.
A systematic literature search was conducted (up to April 2015) in five online databases: PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), WeiPu, and WanFang databases.
The strength of association was calculated by odds ratio (OR) and corresponding 95% confidence interval (CI).
Results.
Seven case-control studies with 1050 cases and 1202 controls were included.
Our study suggested a significant association between the MspI polymorphism and COPD risk (CC versus TC + TT: OR = 1.57, CI: 1.09–2.26, P=0.02; CC versus TT: OR = 1.73, CI: 1.18–2.55, P=0.005).
For the Ile/Val polymorphism, a significant association with COPD risk was observed (GG versus AG + AA: OR = 2.75, CI: 1.29–5.84, P = 0.009; GG versus AA: OR = 3.23, CI: 1.50–6.93, P=0.003; AG versus AA: OR = 1.39, CI: 1.01–1.90, P=0.04).
Subgroup analysis indicated a significant association between the MspI variation and COPD risk among Asians (CC versus TC + TT: OR = 1.70, CI: 1.06–2.71, P=0.03; CC versus TT: OR = 1.84, CI: 1.11–3.06, P=0.02).
Conclusion.
The MspI and Ile/Val polymorphisms might alter the susceptibility of COPD, and MspI polymorphism might play a role in COPD risk among Asian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Cheng-Di& Chen, Nan& Huang, Lin& Wang, Jia-Rong& Chen, Zhi-Yuan& Jiang, Ya-Mei…[et al.]. 2015. Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057327
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Cheng-Di…[et al.]. Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057327
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Cheng-Di& Chen, Nan& Huang, Lin& Wang, Jia-Rong& Chen, Zhi-Yuan& Jiang, Ya-Mei…[et al.]. Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057327
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057327
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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