Acute Effects of Alcohol on the Human Brain: A Resting-State fMRI Study

الملخص EN

The aim of this study is to assess the value of resting-state fMRI in detecting the acute effects of alcohol on healthy human brains.

Thirty-two healthy volunteers were studied by conventional MR imaging and resting-state fMRI prior to and 0.5 hours after initiation of acute alcohol administration.

The fMRI data, acquired during the resting state, were correlated with different breath alcohol concentrations (BrAC).

We use the posterior cingulate cortex/precuneus as a seed for the default mode network (DMN) analysis.

ALFF and ReHo were also used to investigate spontaneous neural activity in the resting state.

Conventional MR imaging showed no abnormalities on all subjects.

Compared with the prior alcohol administration, the ALFF and ReHo also indicated some specific brain regions which are affected by alcohol, including the superior frontal gyrus, cerebellum, hippocampal gyrus, left basal ganglia, and right internal capsule.

Functional connectivity of the DMN was affected by alcohol.

This resting-state fMRI indicates that brain regions implicated are affected by alcohol and might provide a neural basis for alcohol’s effects on behavioral performance.