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Propofol Requirement for Induction of Unconsciousness Is Reduced in Patients with Parkinson’s Disease: A Case Control Study
المؤلفون المشاركون
Deng, Xiaoming
Xu, Xiao-ping
Yu, Xi-ya
Wu, Xi
Hu, Xiao-wu
Chen, Jian-chun
Wang, Jiafeng
Li, Jinbao
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, but whether the neurodegenerative process influences the pharmacodynamics of propofol remains unclear.
We aimed to evaluate the effect of PD on pharmacodynamics of propofol.
A total of 31 PD patients undergoing surgical treatment (PD group) and 31 pair-controlled non-PD patients undergoing intracranial surgery (NPD group) were recruited to investigate the propofol requirement for unconsciousness induction.
Unconsciousness was induced in all patients with target-controlled infusion of propofol.
The propofol concentration at which unconsciousness was induced was compared between the two groups.
EC50 and EC95 were calculated as well.
Demographic data, bispectral index, and hemodynamic values were comparable between PD and NPD groups.
The mean target concentration of propofol when unconsciousness was achieved was 2.32 ± 0.38 μg/mL in PD group, which was significantly lower than that in NPD group (2.90 ± 0.35 μg/mL).
The EC50 was 2.05 μg/mL (95% CI: 1.85–2.19 μg/mL) in PD group, much lower than the 2.72 μg/mL (95% CI: 2.53–2.88 μg/mL) in NPD group.
In conclusion, the effective propofol concentration needed for induction of unconsciousness in 50% of patients is reduced in PD patients.
(This trial is registered with NCT01998204.)
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Xiao-ping& Yu, Xi-ya& Wu, Xi& Hu, Xiao-wu& Chen, Jian-chun& Li, Jinbao…[et al.]. 2015. Propofol Requirement for Induction of Unconsciousness Is Reduced in Patients with Parkinson’s Disease: A Case Control Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1057366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Xiao-ping…[et al.]. Propofol Requirement for Induction of Unconsciousness Is Reduced in Patients with Parkinson’s Disease: A Case Control Study. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1057366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Xiao-ping& Yu, Xi-ya& Wu, Xi& Hu, Xiao-wu& Chen, Jian-chun& Li, Jinbao…[et al.]. Propofol Requirement for Induction of Unconsciousness Is Reduced in Patients with Parkinson’s Disease: A Case Control Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1057366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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