The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

المؤلفون المشاركون

Liu, Kang
Li, Jie
Wang, Xiaolan
Ye, Jiaxin
Qin, Chao
Shao, Pengfei
Zhang, Wei
Yin, Changjun

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-02-01

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

The calcium-sensing receptor gene (CaSR) is a candidate to explain urolithiasis.

A number of case-control studies were conducted to investigate associations between CaSR polymorphisms with risks of hypercalciuria and urolithiasis in humans.

But the results were still inconsistent.

Methods.

A meta-analysis was performed to address this issue.

Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations between CaSR polymorphisms and the risk of urolithiasis.

The pooled standardized mean difference (SMD) with 95% CI was used for the meta-analysis of CaSR polymorphisms and urine calcium concentration.

Results.

For urolithiasis association, the SS genotype of A986S polymorphism was a risk factor for urolithiasis in Asians and PHPT patients, but a protective factor in Caucasians.

The GG genotype of R990 polymorphism was associated with an increased risk of urolithiasis, especially in Caucasians and healthy population.

Regarding urine calcium concentration association, individuals with the G allele had a higher level of urine calcium than the noncarriers.

Conclusions.

This meta-analysis revealed that the G allele of CaSR R990G polymorphism increases susceptibility to urolithiasis and hypercalciuria.

The A986S and Q1011E polymorphisms were associated with urolithiasis and hypercalciuria in specific populations.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Kang& Wang, Xiaolan& Ye, Jiaxin& Qin, Chao& Shao, Pengfei& Zhang, Wei…[et al.]. 2015. The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057376

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Kang…[et al.]. The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057376

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Kang& Wang, Xiaolan& Ye, Jiaxin& Qin, Chao& Shao, Pengfei& Zhang, Wei…[et al.]. The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057376

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1057376