High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy
المؤلفون المشاركون
Moriel, Patricia
Freitas, Betânia de Jesus e Silva de Almendra
Lloret, Gustavo Rafaini
Visacri, Marília Berlofa
Tuan, Bruna Taliani
Amaral, Lais Sampaio
Baldini, Daniele
Sousa, Vanessa Marcílio de
Castro, Laís Lima de
Aguiar, Jordana Rayane Sousa
Pincinato, Eder de Carvalho
Mazzola, Priscila Gava
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects.
Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group.
Materials and Methods.
In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery.
In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo ( n = 34 ) and the other ( n = 26 ) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers.
Results.
In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15- F 2 t -isoprostane was significantly higher than in the healthy subjects.
Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15- F 2 t -isoprostane.
In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers.
Conclusion.
Patients with history of NMSC had significantly high 15- F 2 t -isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers.
This trial was registered with ClinicalTrials.gov (ID NCT02248584).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Freitas, Betânia de Jesus e Silva de Almendra& Lloret, Gustavo Rafaini& Visacri, Marília Berlofa& Tuan, Bruna Taliani& Amaral, Lais Sampaio& Baldini, Daniele…[et al.]. 2015. High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Freitas, Betânia de Jesus e Silva de Almendra…[et al.]. High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Freitas, Betânia de Jesus e Silva de Almendra& Lloret, Gustavo Rafaini& Visacri, Marília Berlofa& Tuan, Bruna Taliani& Amaral, Lais Sampaio& Baldini, Daniele…[et al.]. High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر