In Silico Search of Energy Metabolism Inhibitors for Alternative Leishmaniasis Treatments
المؤلفون المشاركون
Silva, Lourival A.
Vinaud, Marina C.
Castro, Ana Maria
Cravo, Pedro Vítor L.
Bezerra, José Clecildo B.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Leishmaniasis is a complex disease that affects mammals and is caused by approximately 20 distinct protozoa from the genus Leishmania.
Leishmaniasis is an endemic disease that exerts a large socioeconomic impact on poor and developing countries.
The current treatment for leishmaniasis is complex, expensive, and poorly efficacious.
Thus, there is an urgent need to develop more selective, less expensive new drugs.
The energy metabolism pathways of Leishmania include several interesting targets for specific inhibitors.
In the present study, we sought to establish which energy metabolism enzymes in Leishmania could be targets for inhibitors that have already been approved for the treatment of other diseases.
We were able to identify 94 genes and 93 Leishmania energy metabolism targets.
Using each gene’s designation as a search criterion in the TriTrypDB database, we located the predicted peptide sequences, which in turn were used to interrogate the DrugBank, Therapeutic Target Database (TTD), and PubChem databases.
We identified 44 putative targets of which 11 are predicted to be amenable to inhibition by drugs which have already been approved for use in humans for 11 of these targets.
We propose that these drugs should be experimentally tested and potentially used in the treatment of leishmaniasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silva, Lourival A.& Vinaud, Marina C.& Castro, Ana Maria& Cravo, Pedro Vítor L.& Bezerra, José Clecildo B.. 2015. In Silico Search of Energy Metabolism Inhibitors for Alternative Leishmaniasis Treatments. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silva, Lourival A.…[et al.]. In Silico Search of Energy Metabolism Inhibitors for Alternative Leishmaniasis Treatments. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silva, Lourival A.& Vinaud, Marina C.& Castro, Ana Maria& Cravo, Pedro Vítor L.& Bezerra, José Clecildo B.. In Silico Search of Energy Metabolism Inhibitors for Alternative Leishmaniasis Treatments. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر