Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach
المؤلفون المشاركون
Rong, Panying
Yunusova, Yana
Wang, Jun
Green, Jordan R.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
To develop a predictive model of speech loss in persons with amyotrophic lateral sclerosis (ALS) based on measures of respiratory, phonatory, articulatory, and resonatory functions that were selected using a data-mining approach.
Method.
Physiologic speech subsystem (respiratory, phonatory, articulatory, and resonatory) functions were evaluated longitudinally in 66 individuals with ALS using multiple instrumentation approaches including acoustic, aerodynamic, nasometeric, and kinematic.
The instrumental measures of the subsystem functions were subjected to a principal component analysis and linear mixed effects models to derive a set of comprehensive predictors of bulbar dysfunction.
These subsystem predictors were subjected to a Kaplan-Meier analysis to estimate the time until speech loss.
Results.
For a majority of participants, speech subsystem decline was detectible prior to declines in speech intelligibility and speaking rate.
Among all subsystems, the articulatory and phonatory predictors were most responsive to early bulbar deterioration; and the resonatory and respiratory predictors were as responsive to bulbar decline as was speaking rate.
Conclusions.
The articulatory and phonatory predictors are sensitive indicators of early bulbar decline due to ALS, which has implications for predicting disease onset and progression and clinical management of ALS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rong, Panying& Yunusova, Yana& Wang, Jun& Green, Jordan R.. 2015. Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rong, Panying…[et al.]. Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach. Behavioural Neurology No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rong, Panying& Yunusova, Yana& Wang, Jun& Green, Jordan R.. Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر