Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals
المؤلفون المشاركون
Pei, Zhong
Zheng, Yifan
Liu, Yanmei
Zhou, Hongyan
Xian, Wenbiao
Fang, Yingying
Chen, Ling
Wu, Qi
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson’s disease (PD) in Chinese individuals.
As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2.
Purpose.
This study aimed to explore the effects of LRRK2 S1647T polymorphism on cognitive function in PD.
Method.
90 PD patients were randomly recruited.
They underwent a series of clinical evaluations and genetic testing for the LRRK2 S1647T polymorphism.
Global intellect and five cognitive domains (language fluency, visuospatial function, attention, memory, and executive function) were compared between S1647T carriers and noncarriers.
Results.
No differences in motor features were found between two groups, but the executive function evaluation showed that Stroop word colour test time (SWCT-TIME) scores were lower in LRRK2 S1647T carriers than in noncarriers (P=0.017).
However, multiple linear regression analysis indicated that the correlation between S1647T polymorphism and SWCT-TIME scores did not reach significant level (P=0.051).
Conclusion.
Our findings suggest that cognitive impairments are not correlated with different LRRK2 S1647T polymorphisms in Chinese PD individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Yifan& Pei, Zhong& Liu, Yanmei& Zhou, Hongyan& Xian, Wenbiao& Fang, Yingying…[et al.]. 2015. Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1057561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Yifan…[et al.]. Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals. Behavioural Neurology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1057561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Yifan& Pei, Zhong& Liu, Yanmei& Zhou, Hongyan& Xian, Wenbiao& Fang, Yingying…[et al.]. Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1057561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر