Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues
المؤلفون المشاركون
Oboh, Ganiyu
Oyeleye, Idowu S.
Boligon, Aline Augusti
Ademiluyi, Adedayo O.
Olasehinde, Tosin A.
Ademosun, Ayokunle O.
Athayde, Margareth Linde
المصدر
Biochemistry Research International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was designed to determine the antioxidant properties and inhibitory effects of extract from Moringa oleifera leaves on angiotensin-I-converting enzyme (ACE) and arginase activities in vitro.
The extract was prepared and phenolic (total phenols and flavonoid) contents, radical (nitric oxide (NO), hydroxyl (OH)) scavenging abilities, and Fe2+-chelating ability were assessed.
Characterization of the phenolic constituents was done via high performance liquid chromatography-diode array detection (HPLC-DAD) analysis.
Furthermore, the effects of the extract on Fe2+-induced MDA production in rats’ penile tissue homogenate as well as its action on ACE and arginase activities were also determined.
The extract scavenged N O ∗ , O H ∗ , chelated Fe2+, and inhibited MDA production in a dose-dependent pattern with IC50 values of 1.36, 0.52, and 0.38 mg/mL and 194.23 µg/mL, respectively.
Gallic acid, chlorogenic acid, quercetin, and kaempferol were the most abundant phenolic compounds identified in the leaf extract.
The extract also inhibited ACE and arginase activities in a dose-dependent pattern and their IC50 values were 303.03 and 159.59 µg/mL, respectively.
The phenolic contents, inhibition of ACE, arginase, and Fe2+-induced MDA production, and radical ( O H ∗ , N O ∗ ) scavenging and Fe2+-chelating abilities could be some of the possible mechanisms by which M.
oleifera leaves could be used in the treatment and/or management of erectile dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oboh, Ganiyu& Ademiluyi, Adedayo O.& Ademosun, Ayokunle O.& Olasehinde, Tosin A.& Oyeleye, Idowu S.& Boligon, Aline Augusti…[et al.]. 2015. Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues. Biochemistry Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oboh, Ganiyu…[et al.]. Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues. Biochemistry Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oboh, Ganiyu& Ademiluyi, Adedayo O.& Ademosun, Ayokunle O.& Olasehinde, Tosin A.& Oyeleye, Idowu S.& Boligon, Aline Augusti…[et al.]. Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues. Biochemistry Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر