Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat
المؤلفون المشاركون
Olayinka, Ebenezer Tunde
Ore, Ayokanmi
المصدر
Biochemistry Research International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Moxifloxacin is a broad spectrum fluoroquinolone antibacterial agent.
We examined the hepatic redox status and plasma biomarkers of nephrotoxicity and hepatotoxicity in rat following administration of moxifloxacin (MXF).
Twenty-four Wistar rats, 180–200 g, were randomized into four groups (I–IV).
Animals in group I (control) received 1 mL of distilled water, while animals in groups II, III, and IV received 1 mL each of MXF equivalent to 4 mg/kg b.w., 8 mg/kg b.w., and 16 mg/kg b.w., respectively.
After seven days, plasma urea, bilirubin, and creatinine were significantly ( P < 0.05 ) elevated in the MXF-treated animals.
Activities of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase were significantly increased in the plasma of MXF-treated animals compared to control.
Also plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides increased significantly in the MXF-treated groups relative to control.
Moreover, MXF triggered a significant decrease in hepatic catalase, superoxide dismutase, and glutathione- S transferase activities.
Likewise, MXF caused a decrease in the hepatic levels of glutathione and vitamin C.
A significant increase in hepatic MDA content was also observed in the MXF-treated animals relative to control.
Overall, our data suggest that the half-therapeutic, therapeutic, and twice the therapeutic dose of MXF induced nephrotoxicity, hepatotoxicity, and altered hepatic redox balance in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ore, Ayokanmi& Olayinka, Ebenezer Tunde. 2015. Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat. Biochemistry Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057606
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ore, Ayokanmi& Olayinka, Ebenezer Tunde. Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat. Biochemistry Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057606
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ore, Ayokanmi& Olayinka, Ebenezer Tunde. Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat. Biochemistry Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057606
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057606
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر