NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma
المؤلفون المشاركون
Ji, Zhiwei
Wang, Bing
Huang, De-Shuang
Meng, Guanmin
Yue, Xiaoqiang
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy.
Traditional Chinese Medicine (TCM), with the characteristics of syndrome differentiation, plays an important role in the comprehensive treatment of HCC.
This study aims to develop a nonnegative matrix factorization- (NMF-) based feature selection approach (NMFBFS) to identify potential clinical symptoms for HCC patient stratification.
Methods.
The NMFBFS approach consisted of three major steps.
Firstly, statistics-based preliminary feature screening was designed to detect and remove irrelevant symptoms.
Secondly, NMF was employed to infer redundant symptoms.
Based on NMF-derived basis matrix, we defined a novel similarity measurement of intersymptoms.
Finally, we converted each group of redundant symptoms to a new single feature so that the dimension was further reduced.
Results.
Based on a clinical dataset consisting of 407 patient samples of HCC with 57 symptoms, NMFBFS approach detected 8 irrelevant symptoms and then identified 16 redundant symptoms within 6 groups.
Finally, an optimal feature subset with 39 clinical features was generated after compressing the redundant symptoms by groups.
The validation of classification performance shows that these 39 features obviously improve the prediction accuracy of HCC patients.
Conclusions.
Compared with other methods, NMFBFS has obvious advantages in identifying important clinical features of HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Zhiwei& Meng, Guanmin& Huang, De-Shuang& Yue, Xiaoqiang& Wang, Bing. 2015. NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1058017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Zhiwei…[et al.]. NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1058017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Zhiwei& Meng, Guanmin& Huang, De-Shuang& Yue, Xiaoqiang& Wang, Bing. NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1058017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر