The Structural Characterization of Tumor Fusion Genes and Proteins
المؤلفون المشاركون
Zhang, Menghuan
Xie, Lu
Wang, Dandan
Li, Daixi
Qin, Guangrong
Zhang, Wen
Ouyang, Jian
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chromosomal translocation, which generates fusion proteins in blood tumor or solid tumor, is considered as one of the major causes leading to cancer.
Recent studies suggested that the disordered fragments in a fusion protein might contribute to its carcinogenicity.
Here, we investigated the sequence feature near the breakpoints in the fusion partner genes, the structure features of breakpoints in fusion proteins, and the posttranslational modification preference in the fusion proteins.
Results show that the breakpoints in the fusion partner genes have both sequence preference and structural preference.
At the sequence level, nucleotide combination AG is preferred before the breakpoint and GG is preferred at the breakpoint.
At the structural level, the breakpoints in the fusion proteins prefer to be located in the disordered regions.
Further analysis suggests the phosphorylation sites at serine, threonine, and the methylation sites at arginine are enriched in disordered regions of the fusion proteins.
Using EML4-ALK as an example, we further explained how the fusion protein leads to the protein disorder and contributes to its carcinogenicity.
The sequence and structural features of the fusion proteins may help the scientific community to predict novel breakpoints in fusion genes and better understand the structure and function of fusion proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Dandan& Li, Daixi& Qin, Guangrong& Zhang, Wen& Ouyang, Jian& Zhang, Menghuan…[et al.]. 2015. The Structural Characterization of Tumor Fusion Genes and Proteins. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1058035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Dandan…[et al.]. The Structural Characterization of Tumor Fusion Genes and Proteins. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1058035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Dandan& Li, Daixi& Qin, Guangrong& Zhang, Wen& Ouyang, Jian& Zhang, Menghuan…[et al.]. The Structural Characterization of Tumor Fusion Genes and Proteins. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1058035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر