Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option
المؤلفون المشاركون
Zujalovic, Benedikt
Barth, Eberhard
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-13
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Delirium is a common problem in ICU patients, resulting in prolonged ICU stay and increased mortality.
A cholinergic deficiency in the central nervous system is supposed to be a relevant pathophysiologic process in delirium.
Acetylcholine is a major transmitter of the parasympathetic nervous system influencing several organs (e.g., heart and kidneys) and the inflammatory response too.
This perception might explain that delirium is not an individual symptom, but rather a part of a symptom complex with various disorders of the whole organism.
The cholinergic deficiency could not be quantified up to now.
Using the possibility of bedside determination of the acetylcholinesterase activity (AChE activity), we assumed to objectify the cholinergic homeostasis within minutes.
As reported here, the postoperative delirium was accompanied by a massive hemodynamic and renal deterioration of unclear genesis.
We identified the altered AChE activity as a plausible pathophysiological mechanism.
The pharmacological intervention with the indirect parasympathomimetic physostigmine led to a quick and lasting improvement of the patient’s cognitive, hemodynamic, and renal status.
In summary, severe delirium is not always an attendant phenomenon of critical illness.
It might be causal for multiple organ deterioration if it is based on cholinergic deficiency and has to be treated at his pathophysiological roots whenever possible.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zujalovic, Benedikt& Barth, Eberhard. 2015. Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option. Case Reports in Critical Care،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058214
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zujalovic, Benedikt& Barth, Eberhard. Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option. Case Reports in Critical Care No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058214
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zujalovic, Benedikt& Barth, Eberhard. Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option. Case Reports in Critical Care. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058214
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058214
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر