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Marked Direct Hyperbilirubinemia due to Ceftriaxone in an Adult with Sickle Cell Disease
المؤلفون المشاركون
Khurram, Daniyeh
Shamban, Leonid
Kornas, Robert
Paul, Maryann
المصدر
Case Reports in Gastrointestinal Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-25
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Drugs are a significant cause of liver injury.
Drug-induced liver injury (DILI) can cause acute hepatitis, cholestasis, or a mixed pattern.
Ceftriaxone is a commonly used antibiotic and has been associated with reversible biliary sludge, pseudolithiasis, and cholestasis.
A 32-year-old male with sickle cell disease was admitted to the hospital for acute sickle cell crisis.
On the second day of hospitalization, he developed cough and rhonchi with chest X-ray revealing right middle lobe infiltrates.
Ceftriaxone and azithromycin were initiated.
Subsequently, he developed conjugated hyperbilirubinemia and mild transaminitis.
His total bilirubin trended upwards from 3.3 mg/dL on admission to 17 mg/dL.
It was predominantly conjugated bilirubin, with preadmission bilirubin levels of 3-4 mg/dL.
His transaminases were mildly elevated as well compared to previous levels.
Extensive workup for bilirubin elevation was unremarkable.
Ceftriaxone was switched to levofloxacin and the hyperbilirubinemia improved.
On ambulatory follow-up, his bilirubin remained below 4 mg/dL.
Ceftriaxone may be associated with marked direct hyperbilirubinemia particularly in sickle cell patients with chronic liver chemistry abnormalities.
In the case of elevated bilirubin with concomitant ceftriaxone use, elimination of the offending agent should be considered.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khurram, Daniyeh& Shamban, Leonid& Kornas, Robert& Paul, Maryann. 2015. Marked Direct Hyperbilirubinemia due to Ceftriaxone in an Adult with Sickle Cell Disease. Case Reports in Gastrointestinal Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khurram, Daniyeh…[et al.]. Marked Direct Hyperbilirubinemia due to Ceftriaxone in an Adult with Sickle Cell Disease. Case Reports in Gastrointestinal Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khurram, Daniyeh& Shamban, Leonid& Kornas, Robert& Paul, Maryann. Marked Direct Hyperbilirubinemia due to Ceftriaxone in an Adult with Sickle Cell Disease. Case Reports in Gastrointestinal Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058545
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