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Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump
المؤلفون المشاركون
Shamil, Eamon
Cunningham, David
Wong, Billy L. K.
Jani, Piyush
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Tuberculosis is an opportunistic infection with protean clinical manifestations.
We describe a case of Ruxolitinib induced miliary tuberculosis presenting as a neck lump.
A 78-year-old female presented with a two-month history of right-sided neck lump associated with fever, night sweats, and significant weight loss.
She had a past medical history that included myelofibrosis, being treated with Ruxolitinib.
Examination demonstrated 4 × 4 cm right-sided cervical lymphadenopathy.
A chest radiograph showed extensive shadowing in both lungs.
CT scan demonstrated perilymphatic nodes in addition to the cervical mass.
An ultrasound-guided biopsy of a cervical lymph node demonstrated confirmed Mycobacterium tuberculosis infection.
It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient.
The medication was stopped and a 12-month regime of antituberculosis therapy commenced.
She remained well at one-year follow-up with resolution of lung involvement.
Clinicians should consider tuberculosis as a differential diagnosis for patients presenting with a neck lump, particularly in those taking immunosuppressant medication such as Ruxolitinib.
A multidisciplinary approach is needed to promptly treat the tuberculosis and consider discontinuation of Ruxolitinib.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shamil, Eamon& Cunningham, David& Wong, Billy L. K.& Jani, Piyush. 2015. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shamil, Eamon…[et al.]. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shamil, Eamon& Cunningham, David& Wong, Billy L. K.& Jani, Piyush. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058700
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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