Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump
المؤلفون المشاركون
Shamil, Eamon
Cunningham, David
Wong, Billy L. K.
Jani, Piyush
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Tuberculosis is an opportunistic infection with protean clinical manifestations.
We describe a case of Ruxolitinib induced miliary tuberculosis presenting as a neck lump.
A 78-year-old female presented with a two-month history of right-sided neck lump associated with fever, night sweats, and significant weight loss.
She had a past medical history that included myelofibrosis, being treated with Ruxolitinib.
Examination demonstrated 4 × 4 cm right-sided cervical lymphadenopathy.
A chest radiograph showed extensive shadowing in both lungs.
CT scan demonstrated perilymphatic nodes in addition to the cervical mass.
An ultrasound-guided biopsy of a cervical lymph node demonstrated confirmed Mycobacterium tuberculosis infection.
It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient.
The medication was stopped and a 12-month regime of antituberculosis therapy commenced.
She remained well at one-year follow-up with resolution of lung involvement.
Clinicians should consider tuberculosis as a differential diagnosis for patients presenting with a neck lump, particularly in those taking immunosuppressant medication such as Ruxolitinib.
A multidisciplinary approach is needed to promptly treat the tuberculosis and consider discontinuation of Ruxolitinib.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shamil, Eamon& Cunningham, David& Wong, Billy L. K.& Jani, Piyush. 2015. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shamil, Eamon…[et al.]. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shamil, Eamon& Cunningham, David& Wong, Billy L. K.& Jani, Piyush. Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump. Case Reports in Infectious Diseases. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058700
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1058700
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر