Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face
المؤلفون المشاركون
Block, Alec M.
Alite, Fiori
Diaz, Aidnag Z.
Borrowdale, Richard W.
Clark, Joseph I.
Choi, Mehee
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
For large basal cell carcinomas (BCCs) of the head and neck, definitive surgery often requires extensive resection and reconstruction that may result in prolonged recovery and limited cosmesis.
Vismodegib, a small-molecule inhibitor of the hedgehog pathway, is approved for advanced and metastatic BCCs.
We present a case of advanced BCC treated with combination of vismodegib, radiotherapy, and local excision resulting in excellent response and cosmesis.
Case Presentation.
A 64-year-old gentleman presented with a 5-year history of a 7 cm enlarging right cheek mass, with extensive vascularization, central ulceration, and skin, soft tissue, and buccal mucosa involvement.
Biopsy revealed BCC, nodular type.
Up-front surgical option involved a large resection and reconstruction.
After multidisciplinary discussion, we recommended and he opted for combined modality of vismodegib, radiotherapy, and local excision.
The patient tolerated vismodegib well and his right cheek lesion decreased significantly in size.
He was then treated with radiotherapy followed by local excision that revealed only focal residual BCC.
Currently, he is without evidence of disease and has excellent cosmesis.
Conclusions.
We report a case of locally advanced BCC treated with trimodality therapy with vismodegib, radiotherapy, and local excision, resulting in excellent outcome and facial cosmesis, without requiring extensive resection or reconstructive surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Block, Alec M.& Alite, Fiori& Diaz, Aidnag Z.& Borrowdale, Richard W.& Clark, Joseph I.& Choi, Mehee. 2015. Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059317
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Block, Alec M.…[et al.]. Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1059317
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Block, Alec M.& Alite, Fiori& Diaz, Aidnag Z.& Borrowdale, Richard W.& Clark, Joseph I.& Choi, Mehee. Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059317
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059317
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر