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Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature
المؤلفون المشاركون
Edwards, Kristin
Barth, Peter
Dulaimi Al-Saleem, Essel
Millis, Sherri Z.
Wong, Yu-Ning
Geynisman, Daniel M.
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Extramammary Paget’s disease (EMPD) is a rare cancer.
Although EMPD is usually noninvasive and treated with local therapy, oncemetastatic the prognosis of EMPD is poor and treatment options are limited.
We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2/neu overexpressed EMPD of the scrotum.
Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD) cases was completed and revealed multiple biomarker aberrations.
Overexpression of Her2 was frequently noted (30%–40%) in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents.
Trastuzumab therapy can be safely utilized in a hemodialysis patient.
In addition, multiple protein overexpression and loss were seen in EMPD including PD-1, PD-L1, PTEN, and AR as well as PIK3CA mutation.
These findings may lead to possible therapeutic interventions targeting these pathways in a disease with few effective treatment options.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barth, Peter& Dulaimi Al-Saleem, Essel& Edwards, Kristin& Millis, Sherri Z.& Wong, Yu-Ning& Geynisman, Daniel M.. 2015. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barth, Peter…[et al.]. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barth, Peter& Dulaimi Al-Saleem, Essel& Edwards, Kristin& Millis, Sherri Z.& Wong, Yu-Ning& Geynisman, Daniel M.. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059326
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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