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Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature
Joint Authors
Edwards, Kristin
Barth, Peter
Dulaimi Al-Saleem, Essel
Millis, Sherri Z.
Wong, Yu-Ning
Geynisman, Daniel M.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Extramammary Paget’s disease (EMPD) is a rare cancer.
Although EMPD is usually noninvasive and treated with local therapy, oncemetastatic the prognosis of EMPD is poor and treatment options are limited.
We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2/neu overexpressed EMPD of the scrotum.
Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD) cases was completed and revealed multiple biomarker aberrations.
Overexpression of Her2 was frequently noted (30%–40%) in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents.
Trastuzumab therapy can be safely utilized in a hemodialysis patient.
In addition, multiple protein overexpression and loss were seen in EMPD including PD-1, PD-L1, PTEN, and AR as well as PIK3CA mutation.
These findings may lead to possible therapeutic interventions targeting these pathways in a disease with few effective treatment options.
American Psychological Association (APA)
Barth, Peter& Dulaimi Al-Saleem, Essel& Edwards, Kristin& Millis, Sherri Z.& Wong, Yu-Ning& Geynisman, Daniel M.. 2015. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
Modern Language Association (MLA)
Barth, Peter…[et al.]. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
American Medical Association (AMA)
Barth, Peter& Dulaimi Al-Saleem, Essel& Edwards, Kristin& Millis, Sherri Z.& Wong, Yu-Ning& Geynisman, Daniel M.. Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059326