Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review
المؤلفون المشاركون
Sugimura, Haruhiko
Kuroda, Shiho
Kurita, Akira
Muraki, Mari
Aoshima, Yoichiro
Suzuki, Shioto
Tanioka, Fumihiko
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive malignancy.
In more than two-thirds of these NMC cases, a fusion between NUT and BRD4 or BRD3 has been documented; other variants are rare.
The cytology of NMC itself has been sparsely documented and that of variant NMC has never been reported.
Case Presentation.
A 36-year-old woman was admitted because of a rapidly progressing lung tumor with metastases to the breast and bone.
We recently reported this patient as the first case of a variant NMC of the lung harboring an NSD3-NUT fusion, based on immunohistochemical and genetic analyses.
Cytological material was available for the present review.
A highly cellular smear contained a predominantly noncohesive pattern of monomorphic cells with diameters 2–2.5 times greater than those of small lymphocytes, with a round-to-oval nucleus, slightly irregular nuclear contours, variably prominent nucleoli, scant cytoplasm, and identifiable mitotic figures.
Foci of stratification and overt pearl formation, including a dyskeratocyte, were occasionally observed.
The necrotic background contained naked nuclei, karyorrhectic debris, apoptotic cells, and macrophages phagocytizing karyorrhectic debris; nuclear crushing was noted.
Conclusion.
The cytological features of a variant NMC of the lung are described for the first time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuroda, Shiho& Suzuki, Shioto& Kurita, Akira& Muraki, Mari& Aoshima, Yoichiro& Tanioka, Fumihiko…[et al.]. 2015. Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review. Case Reports in Pathology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuroda, Shiho…[et al.]. Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review. Case Reports in Pathology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuroda, Shiho& Suzuki, Shioto& Kurita, Akira& Muraki, Mari& Aoshima, Yoichiro& Tanioka, Fumihiko…[et al.]. Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review. Case Reports in Pathology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1059719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر